The Study
Introduction of Clinical & Research Achievements of Director Ohtsuru
We feature scenes from conference presentations focused on biotherapy, along with a record of numerous research achievements.
Oral Presentation: The 3rd Annual Meeting of the Japanese Knee Osteotomy and Joint Preservation Society (2024)
Conference Presentations
Presentations have been given at the Annual Meeting of the Japanese Orthopedic Association, the Annual Meeting of the Japanese Society for Regenerative Medicine, and the Annual Meeting of the Japanese Knee Osteotomy and Joint Preservation Society.
1，The 18th Congress of the Japanese Society for Regenerative Medicine (March 21–23, 2019, Kobe)
Current Status and Challenges of Regenerative Medicine for the Knee Joint Performed as Private Practice (Symposium)
Tadahiko Ohtsuru, Naomasa Yokota, Marin Hattori, Masaki Otsuji
2. The 19th Annual Meeting of the Japanese Society for Regenerative Medicine (March 12–14, 2020, Online)
Symposium: Establishing Evidence and Promoting Social Understanding of Biologic Therapy for Knee Osteoarthritis
Tadahiko Ohtsuru, Naomasa Yokota, Yushi Maekawa, Masaki Otsuji, Shingo Yasuda, Akira Koshiishi
3. The 93rd Annual Meeting of the Japanese Orthopedic Association
(May 21–24, 2020, Online)
Treatment Outcomes of Intra-articular Injection of Adipose-derived Mesenchymal Stem Cells (ASCs) for Knee Osteoarthritis
Tadahiko Ohtsuru, Naomasa Yokota, Masaki Otsuji, Shingo Yasuda, Akira Koshiishi, Ken Okazaki
4. The 93rd Annual Meeting of the Japanese Orthopedic Association (May 21–24, 2020, Online)
Treatment Outcomes of Intra-articular Injection of Freeze-dried Platelet-derived Factor Concentrate (PFC-FD) for Knee Osteoarthritis
Tadahiko Ohtsuru, Naomasa Yokota, Masaki Otsuji, Shingo Yasuda, Akira Koshiishi, Ken Okazaki
5. The 94th Annual Meeting of the Japanese Orthopedic Association (May 20–23, 2021, Tokyo)
Evaluation of Articular Cartilage Using an MRI 3D Image Analysis Workstation in Biotherapy for Knee Osteoarthritis
Tadahiko Ohtsuru, Naomasa Yokota, Yushi Maekawa, Masaki Otsuji, Shingo Yasuda, Akira Koshiishi, Ken Okazaki
6. The 21st Annual Meeting of the Japanese Society for Regenerative Medicine (March 17–19, 2022, Online)
PFC-FD Therapy for Knee Osteoarthritis: Evaluation of Articular Cartilage Using SYNAPSE VINCENT
Tadahiko Ohtsuru, Yushi Maekawa, Masaki Otsuji, Shingo Yasuda, Ken Okazaki
7. The 95th Annual Meeting of the Japanese Orthopedic Association (May 19–22, 2022, Kobe)
Evaluation of Articular Cartilage Using MRI 3D Automatic Analysis Software After Intra-articular PFC-FD Injection for Knee Osteoarthritis: Single vs. Triple Injections
Tadahiko Ohtsuru, Naomasa Yokota, Yushi Maekawa, Masaki Otsuji, Shingo Yasuda, Ken Okazaki
8. The 2nd Annual Meeting of the Japanese Knee Osteotomy & Joint Preservation Society (October 1, 2022, Tokyo)
Clinical Outcomes of Biotherapy Alone (Panel Discussion)
Tadahiko Ohtsuru, Yushi Maekawa, Masaki Otsuji, Ken Okazaki
9. The 22nd Annual Meeting of the Japanese Society for Regenerative Medicine (March 24, 2023, Kyoto)
Patient-reported Outcomes of Biotherapy for Knee Osteoarthritis: Two-year Results
Tadahiko Ohtsuru, Yushi Maekawa, Masaki Otsuji, Ken Okazaki
10. The 96th Annual Meeting of the Japanese Orthopedic Association (May 13, 2023, Yokohama)
Treatment Outcomes of a Single Intra-articular PFC-FD Injection for Meniscal Injury Triggered by Sports Activity (Symposium)
Tadahiko Ohtsuru, Yushi Maekawa, Rinako Kosaka, Masaki Otsuji, Ken Okazaki
11. The 23rd Annual Meeting of the Japanese Society for Regenerative Medicine (March 21, 2024, Niigata)
Patient-reported Outcomes After Intra-articular Injection of Freeze-dried Platelet-derived Factor Concentrate (PFC-FD) for Knee Osteoarthritis
Tadahiko Ohtsuru, Rinako Kosaka, Yushi Maekawa, Masaki Otsuji, Ken Okazaki, Kensei Nakamura
12. The 3rd Annual Meeting of the Japanese Knee Osteotomy & Joint Preservation Society (April 2024, Takamatsu)
Intra-articular Injection of Freeze-dried Platelet-derived Factor Concentrate (PFC-FD) Is a Safe and Effective Treatment for Early Knee Osteoarthritis
Tadahiko Ohtsuru, Rinako Kosaka, Yushi Maekawa, Masaki Otsuji, Ken Okazaki, Kensei Nakamura
13. The 98th Annual Meeting of the Japanese Orthopedic Association (May 2025, Tokyo)
Evaluation of Articular Cartilage Using 3D MRI After Intra-articular Injections of Adipose-derived Stem Cells (ASC) and Freeze-dried Platelet-derived Factor Concentrate (PFC-FD) for Knee Osteoarthritis
Tadahiko Ohtsuru, Rinako Kosaka, Yushi Maekawa, Ken Okazaki, Kensei Nakamura
Oral Presentation: Evening Seminar, The 1st Annual Meeting of the Japanese Knee Osteotomy and Joint Preservation Society (2021)
Research Achievements
I have authored numerous academic papers on knee osteoarthritis.
1，Freeze-dried noncoagulating platelet-derived factor concentrate is a safe and effective treatment for early knee osteoarthritis
Ohtsuru, T. Otsuji, M. Nakanishi, J. Nakamura, N. Lyman, S. Hanai, H. Shimomura, K. Ando,
W. Knee Surg Sports Traumatol Arthrosc. 2023 Nov;31(11):4716-4723.
2. Practical Approaches and Evidence Building at a Specialized Biologic Healing Clinic for Knee Osteoarthritis (Special Feature: Stem Cells, PRP, and Shockwave Therapy — Evidence of Biologic Healing)
Tadahiko Ohtsuru, Naomasa Yokota, Masaki Otsuji, Shingo Yasuda, Akira Koshiishi, Ken Okazaki.
Joint Surgery 39(9): 33–42, 2020.
3. Evaluation of Articular Cartilage Using SYNAPSE VINCENT in Biotherapy for Knee Osteoarthritis
Tadahiko Ohtsuru, Yushi Maekawa, Masaki Otsuji, Ken Okazaki.
Joint Surgery 41(5): 105–109, 2022.
4. Evaluation of Articular Cartilage Using MRI 3D Automatic Analysis Software After Intra-articular PFC-FD Injection for Knee Osteoarthritis: Single vs. Triple Injections
Tadahiko Ohtsuru, Yushi Maekawa, Masaki Otsuji, Ken Okazaki.
Joint Surgery 41(11): 117–121, 2022.
5. Biotherapy for Knee Osteoarthritis
(Special Feature: Approaching the Pathology of Osteoarthritis — Perspectives on Disease-modifying Treatments)
Tadahiko Ohtsuru, Jun Nakanishi, Masaki Otsuji, Ken Okazaki, Kensei Nakamura.
Orthopedic Surgery and Traumatology 66(12): 1481–1485, 2023.
6. Treatment Outcomes of PFC-FD Injection for Meniscal Injury Triggered by Sports Activity
Tadahiko Ohtsuru, Rinako Kosaka, Yushi Maekawa, Masaki Otsuji, Ken Okazaki, Kensei Nakamura.
Joint Surgery 43(4): 111–117, 2024.
7. Rate of Change in Cartilage Volume Before and After Biotherapy for Knee Osteoarthritis: MRI 3D Analysis
(Special Feature: Cutting-edge Conservative Therapies for Musculoskeletal Disorders in Outpatient Settings)
Tadahiko Ohtsuru, Rinako Kosaka, Yushi Maekawa, Ken Okazaki, Kensei Nakamura.
Joint Surgery (Supplement) 43(14): 132–137, 2024.
8. Who Benefits from PRP Therapy? (Feature: Outpatient Treatment Techniques for Knee Joint Disorders)
Tadahiko Ohtsuru, Ken Okazaki, Kensei Nakamura.
Joint Surgery 44(9): 63–70, 2025.
Symposium Oral Presentation: The 96th Annual Meeting of the Japanese Orthopedic Association (2023)
Lectures and Teaching Activities
1. Prospects for Pain Management in Knee Osteoarthritis (July 11, 2019, Tokyo)
Tokyo Orthopedic Surgery Seminar
2. Adipose-Derived Mesenchymal Stem Cell (ASC) Injection for Knee Osteoarthritis (November 19, 2020, Tokyo)
Juntendo University, Department of Sports Medicine and Regenerative Medicine – ASC Therapy Workshop
3. Practice of Specialized Facilities for Biotherapy – Efforts Toward Establishing Evidence-Based Medicine (EBM) and Promoting Social Understanding – (December 18, 2021, Kobe)
The 1st Evening Seminar of the Japanese Knee Osteotomy & Joint Preservation Society
4. Pain Management for Knee Osteoarthritis in Orthopedic Clinics (June 24, 2025, Shizuoka)
In-House Training Session, Section 3, Tokai-Hokuriku Branch, Nippon Zoki Pharmaceutical Co., Ltd.
5. Indications and Informed Consent for PRP Injections (July 9, 2025, Online)
In-House Seminar, CellSource Co., Ltd.
6. Pharmacotherapy for Musculoskeletal Pain (July 15, 2025, Shizuoka)
Medical Information Representative Training Session, Hisamitsu Pharmaceutical Co., Inc.
7. How to Use PFC-FD? – Realities of Informed Consent Revealed from PRP Topics and Experience with 4,000 Knees – (August 27, 2025, Online)
CellSource Web Seminar